From: Optimization of osteoporosis and osteopenia management among renal transplant recipients
Parameter (reference) | Denosumab (n = 52) | Ibandronate (n = 48) | P-value |
---|---|---|---|
Vitamin D (75–250 nmol/L) | 62.2 (± 6.2) | 56 (± 7.1) | 0.15a |
Calcium (2.2–2.5 mmol/L) | 2.30 (± 0.15) | 2.33 (± 0.16) | 0.67a |
Phosphorous (0.8–1.5 mmol/L) | 1.19 (± 0.14) | 1.17 (± 0.19) | 0.69a |
Serum creatinine (40–115 µmol/L) | 107.3 (± 25.5) | 109.2 (± 26.3) | 0.68a |
Urea (2.5–6.4 mmol/L) | 6.1 (± 2.3) | 5.55 (± 2.62) | 0.18a |
Sodium (135–145 mmol/L) | 138.52 (± 3.4) | 138.7 (± 3.9) | 0.69a |
Chloride (98–107 mmol/L) | 103.5 (± 3.1) | 103.6 (± 3.31) | 0.79a |
Uric acid (208–425 µmol/L) | 343.81 (± 75) | 351.68 (± 69) | 0.31a |
Reported side effects | |||
Injection site reaction | 10 (20%) | 0 | – |
Stomach upset | 0 | 11 (22.9%) | 0.001b |
Abdominal pain | 8 (15.4%) | 9 (18.75%) | 0.65a |
Diarrhea and vomiting | 5 (9.6%) | 15 (31.25%) | 0.006b |
Hypocalcaemia | 6 (11.5%) | 1 (2.1%) | 0.037b |
Fractures | 0 | 0 | – |
Acute rejection | 0 | 0 | – |