From: Characterization of novel stress degradation products of Bempedoic acid and Ezetimibe using UPLC–MS/MS: development and validation of stability-indicating UPLC method
Change in parameter
%RSD of Bempedoic acid
%RSD of Ezetimibe
Flow (0.8 ml/min)
1.24
1.22
Flow (1.2 ml/min)
0.84
0.79
Org Phase (45:55)
1.36
1.65
Org Phase (55:45)
0.97
0.77
Wavelength (225 nm)
0.82
0.85
Wavelength (235 nm)
0.81