Table 7 Comparison between efficacy profiling and toxicity profiling of Olmesartan medoxomil
Drug-1 | Drug-2 | ||||
|---|---|---|---|---|---|
Olmesartan medoxomil | Hydrochlorothiazide | ||||
Protein | Group | Vina binding affinity | Protein | Group | Free energy |
Tyrosine protein kinase JAK2 receptor | Efficacy | − 8.5 | Carbonic amhydrases | Efficacy | N/A |
Caspase-8 | Toxicity | − 7.1 | Glutamate receptor ionotropic, AMPA 1, AMPA 2 | Efficacy | N/A |
COX-2 | Toxicity | − 8.3 | |||