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Future Journal of Pharmaceutical Sciences

Table 9 Ruggedness data

From: Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography

Name of OVI

%RSD for different analysts and days

Day-1

Analyst-1&2 (n = 12)

Day-2

Analyst-1&2 (n = 12)

Analyst-1

Day-1&2 (n = 12)

Methanol

1.5

2.6

6.2

Ethanol

2

0.6

2.7

Acetonitrile

12.62

12.1

13.9

IPA

2.2

0.8

3

DCM

2

0.5

2.1

MTBE

1.5

0.6

3.7

Ethyl acetate

1.5

0.2

1.8

THF

1.4

0.2

2.7

1,4-Dioxane

2.8

0.7

2.6

DMF

10.7

4.7

10

Toluene

2.4

0.4

3

Hexanes

1.5

1.4

5.3

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