Skip to main content

Table 9 Ruggedness data

From: Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography

Name of OVI %RSD for different analysts and days
Day-1
Analyst-1&2 (n = 12)
Day-2
Analyst-1&2 (n = 12)
Analyst-1
Day-1&2 (n = 12)
Methanol 1.5 2.6 6.2
Ethanol 2 0.6 2.7
Acetonitrile 12.62 12.1 13.9
IPA 2.2 0.8 3
DCM 2 0.5 2.1
MTBE 1.5 0.6 3.7
Ethyl acetate 1.5 0.2 1.8
THF 1.4 0.2 2.7
1,4-Dioxane 2.8 0.7 2.6
DMF 10.7 4.7 10
Toluene 2.4 0.4 3
Hexanes 1.5 1.4 5.3