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Table 10 Solution stability

From: Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography

Time interval Methanol % of variation Ethanol % of variation Acetonitrile % of variation IPA % of variation DCM % of variation MTBE % of variation EA % of variation
After 12 h − 0.4 − 2.4 − 1.6 − 2.6 − 1.7 − 1.3 − 1.7
After 24 h − 0.3 − 1.4 − 0.2 − 1.9 − 0.6 − 1.1 − 1.3
After 48 h 2 0.9 3.3 2.1 2.6 0.5 1.1
Time interval THF % of Variation 1,4-Dioxane % of Variation DMF % of Variation Toluene % of Variation Hexanes % of Variation
After 12 h − 1.5 − 1.9 0.9 − 2.4 − 1.3
After 24 h − 1.3 − 0.2 − 5.2 − 1.4 − 1.5
After 48 h 0.4 − 0.2 7.1 1.6 − 1.2