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Table 10 Solution stability

From: Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography

Time interval

Methanol % of variation

Ethanol % of variation

Acetonitrile % of variation

IPA % of variation

DCM % of variation

MTBE % of variation

EA % of variation

After 12 h

− 0.4

− 2.4

− 1.6

− 2.6

− 1.7

− 1.3

− 1.7

After 24 h

− 0.3

− 1.4

− 0.2

− 1.9

− 0.6

− 1.1

− 1.3

After 48 h

2

0.9

3.3

2.1

2.6

0.5

1.1

Time interval

THF % of Variation

1,4-Dioxane % of Variation

DMF % of Variation

Toluene % of Variation

Hexanes % of Variation

After 12 h

− 1.5

− 1.9

0.9

− 2.4

− 1.3

After 24 h

− 1.3

− 0.2

− 5.2

− 1.4

− 1.5

After 48 h

0.4

− 0.2

7.1

1.6

− 1.2