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Table 2 System precision data

From: Quantification of organic volatile impurities in Oseltamivir phosphate drug substances by head space gas chromatography

No of injections

Peak areas

Methanol

Ethanol

Acetonitrile

IPA

DCM

MTBE

Ethyl acetate

1

286.66

454.05

46.85

471.52

36.17

4470.86

982.84

2

258.7

443.7

45.24

462.03

35.3

4406.22

964.7

3

260.6

451.7

46.03

469.01

35.7

4407.46

970.3

4

267.99

454.64

45.92

473.38

35.78

4498.06

976.72

5

282.98

463.53

47.53

482.04

36.54

4473.67

992.4

6

286.41

464.41

48.15

487.92

36.26

4421.39

984.88

Avg

273.9

455.3

46.6

474.3

36

4446.3

978.6

STDEV

12.997

7.749

1.092

9.301

0.449

39.413

10.134

%RSD

4.7

1.7

2.3

2

1.2

0.9

1

No of injections

Peak areas

THF

1,4-Dioxane

DMF

Toluene

Hexanes

1

266.16

27.79

8.37

192.18

613.03

2

262.23

27.2

7.67

187.52

607.53

3

263.57

27.42

7.44

188.88

606.39

4

265.19

27.62

8.03

191.38

627.26

5

268.5

28.33

7.99

194.33

608.18

6

265.31

28.98

9.87

199.53

604.22

Avg

265.2

27.9

8.2

192.3

611.1

STDEV

2.158

0.658

0.865

4.285

8.434

%RSD

0.8

2.4

10.5

2.2

1.4

  1. Bold values indicate better results than other filtering methods