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Table 8 Comparison between existing and proposed method

From: Stability-indicating RP-HPLC method development and validation for estimation of Mupirocin calcium in bulk and in pharmaceutical formulation

Particulars Existing method Proposed method
Solvent Acetonitrile (more expensive) Methanol (less expensive)
Mobile phase mixture Acetonitrile-ammonium acetate Methanol–water
Retention time 7.20 ± 0.07 min(longer) 5.09 ± 0.02 min (shorter)
LOD 9.5 ng/mL 0.35 μg/mL
LOQ 30.6 ng/mL 1.08 μg/mL
Peak tailing factor 1.5 (good) 1.32 (better)