Table 2 Composition and permeation parameters of selected MEL-loaded ME formulae (mean ± SD, n = 3)
Formulation code | Composition % (w/w) | Permeability coefficient P (cm/h) × 10−5 | Steady-state flux Jss (μg/cm2/h) | |||
|---|---|---|---|---|---|---|
Coconut oil | Tween80 | PEG400 | Water | |||
MEL in PBS | – | – | – | – | 0.0029 ± 1.2 | 14.337 ± 1.4 |
MEL in coconut oil | 100 | – | – | – | 0.0136 ± 0.7 | 67.903 ± 0.08 |
TPA5 | 16.6 | 8.3 | 8.3 | 66.6 | 0.005 ± 1.1 | 24.801 ± 1.2 |
TPA7 | 23.3 | 5 | 5 | 66.6 | 0.0118 ± 0.15 | 58.938 ± 0.19 |
TPB5 | 16.6 | 11.0 | 5.5 | 66.6 | 0.0046 ± 0.5 | 23.148 ± 0.4 |
TPB7 | 23.3 | 6.6 | 3.3 | 66.6 | 0.0067 ± 0.7 | 33.386 ± 0.9 |
TPC5 | 16.6 | 12.45 | 4.15 | 66.6 | 0.0035 ± 0.9 | 17.474 ± 0.86 |
TPC7 | 23.3 | 7.5 | 2.5 | 66.6 | 0.0107 ± 2.1 | 53.524 ± 2.3 |
TPD5 | 16.6 | 13.28 | 3.32 | 66.6 | 0.0035 ± 2.3 | 17.737 ± 2.1 |
TPD7 | 23.3 | 8 | 2 | 66.6 | 0.0065 ± 0.4 | 32.504 ± 0.5 |