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Table 1 Summarizes the list of genes and their details associated with the PARK loci in Parkinson’s disease [86, 87]

From: Detailed insight into the pathophysiology and the behavioral complications associated with the Parkinson's disease and its medications

S. nos.

Name

Chromosome

Gene

Inheritance

Protein name

Mutation

1.

PARK 1

4q21-q22

α-Synuclein

Autosomal dominant

α-Synuclein

Lewy body and protein aggregation

2.

PARK 2

6q25.2-q27

Parkin

Autosomal recessive

Parkin E3 ligase

Cause functional mutation

3.

PARK 3

2p13

–

Autosomal dominant

–

–

4.

PARK 4

4q

Copies of α-synuclein

Autosomal dominant

–

Triplications of chromosomal

Region that contains wild-type α-synuclein gene

5.

PARK 5

4p14

Ubiquitin C-terminal hydrolase L1

Autosomal dominant

9ubiquitin-carboxyl-terminal-hydrolase L

–

6.

PARK 6

1p35-p36

–

Autosomal recessive

PINK1 protein kinase

–

7.

PARK 7

1p36

DJ-1

Autosomal recessive

DJ-1

–

8.

PARK 8

12p11.2-q13.1

–

Autosomal dominant

Dardarin

–