Table 1 Summarizes the list of genes and their details associated with the PARK loci in Parkinson’s disease [86, 87]
S. nos. | Name | Chromosome | Gene | Inheritance | Protein name | Mutation |
|---|---|---|---|---|---|---|
1. | PARK 1 | 4q21-q22 | α-Synuclein | Autosomal dominant | α-Synuclein | Lewy body and protein aggregation |
2. | PARK 2 | 6q25.2-q27 | Parkin | Autosomal recessive | Parkin E3 ligase | Cause functional mutation |
3. | PARK 3 | 2p13 | – | Autosomal dominant | – | – |
4. | PARK 4 | 4q | Copies of α-synuclein | Autosomal dominant | – | Triplications of chromosomal Region that contains wild-type α-synuclein gene |
5. | PARK 5 | 4p14 | Ubiquitin C-terminal hydrolase L1 | Autosomal dominant | 9ubiquitin-carboxyl-terminal-hydrolase L | – |
6. | PARK 6 | 1p35-p36 | – | Autosomal recessive | PINK1 protein kinase | – |
7. | PARK 7 | 1p36 | DJ-1 | Autosomal recessive | DJ-1 | – |
8. | PARK 8 | 12p11.2-q13.1 | – | Autosomal dominant | Dardarin | – |