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Table 13 Results of forced degradation studies (n = 6)

From: Experimental design approach, screening and optimization of system variables, analytical method development of flurbiprofen in nanoparticles and stability-indicating methods for high-pressure liquid chromatography

Degradation condition Number of degradation products (Rt values) %Area of degradation product %Drug degraded
Oxidation 3 (2.24, 2.32, 2.60) 22.45, 44.10, 9.85 76.41
Acid 3 (2.27, 2.68, and 7.06) 40.69, 3.63, 3.78 48.12
Base 6 (2.06, 2.42, 2.68, 2.77,2.99, 4.07) 2.07, 7.75, 0, 19.45, 23.27, 43.92 96.49
Neutral 0 0 0
Photo (sunlight) 1 0.20 >1
Thermal 2 (2.23, 3.13) 5.57, 0.74 6.32