Table 5 Formulation parameters optimization by 32 full factorial design
From: Development and evaluation of ultradeformable vesicles loaded transdermal film of boswellic acid
Batch no. | Amount of lecithin (X1) (mg) | Concentration of surfactant (X2) (%) | Vesicle size (Y1) (nm) | Drug EE(Y2) (%) |
|---|---|---|---|---|
BA 10 | 150 | 0.5 | 247.9 ± 0.219 | 86.68 ± 0.553 |
BA 11 | 200 | 0.5 | 283.6 ± 0.355 | 91.17 ± 0.267 |
BA 12 | 250 | 0.5 | 317.7 ± 0.314 | 95.63 ± 0.392 |
BA 13 | 150 | 0.75 | 193.5 ± 0.268 | 85.57 ± 0.561 |
BA 14 | 200 | 0.75 | 266.3 ± 0.347 | 90.52 ± 1.133 |
BA 15 | 250 | 0.75 | 305.8 ± 0.532 | 92.85 ± 0.619 |
BA 16 | 150 | 1 | 187.5 ± 1.122 | 82.72 ± 0.546 |
BA 17 | 200 | 1 | 242.9 ± 0.598 | 88.25 ± 0.367 |
BA 18 | 250 | 1 | 300.8 ± 0.361 | 96.92 ± 0.466 |