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Table 1 Demographic profile of the patients with and without DPH-induced ADRs

From: Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

Parameters

Cases (n = 142)

Control (n = 100)

p value

Male

76

54

NS

Female

66

46

NS

Mean (± SD) age in years

29.6 ± 12.7

31.30 ± 11.59

NS

Mean (± SD) age of onset of seizure in years

19.89 ± 12.81

20.13 ± 11.76

NS

Type of seizures

Generalized tonic & clonic

78

73

NS

Simple partial

16

4

Simple partial with secondary generalization

29

13

Complex partial

3

3

Complex partial with secondary generalization

7

5

Occurrence of status epilepticus

22

8

NS

Presence of frequency of seizures

1–2/ month

15

15

NS

3/month

6

1

 > 3/ month

9

2

(< 1/month)

112

82

Positive family history

35

23

NS

Seizure control

Excellent: No recurrence

101

91

0.002

Good-1/6 months

25

6

Poor-2/6 months to 1/month

6

0

Very poor > 1/month

10

3

Imaging (computed tomography or magnetic resonance imaging)

Normal

64

47

NS

Abnormal

64

42

 

Electroencephalography

Normal

71

58

NS

Abnormal

31

15

Type of epilepsy

Cryptogenic/idiopathic

73

54

NS

Symptomatic

69

46

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