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Table 7 Stability data of Pemigatinib sSNEDDS

From: Formulation development, optimization and characterization of Pemigatinib-loaded supersaturable self-nanoemulsifying drug delivery systems

Parameter

Temperature (°C)

0 days

90 days

180 days

Average droplet size (nm)

4 ± 1 °C

166.78 ± 3.14

172.46 ± 4.26

173.56 ± 3.86

 

25 ± 2 °C

166.78 ± 3.14

167.56 ± 2.28

172.48 ± 4.53

 

40 ± 2 °C

166.78 ± 3.14

170.92 ± 5.12

169.89 ± 3.86

Zeta potential (mV)

4 ± 1 °C

−25.65 ± 2.1

−23.36 ± 2.2

−24.22 ± 3.1

 

25 ± 2 °C

−25.65 ± 2.1

−24.58 ± 3.2

−25.12 ± 1.9

 

40 ± 2 °C

−25.65 ± 2.1

−23.88 ± 4.1

−24.86 ± 2.7

Polydispersity index

4 ± 1 °C

0.256 ± 0.005

0.273 ± 0.005

0.276 ± 0.005

 

25 ± 2 °C

0.256 ± 0.005

0.294 ± 0.005

0.282 ± 0.005

 

40 ± 2 °C

0.256 ± 0.005

0.297 ± 0.005

0.278 ± 0.005

  1. n = 3 (p < 0.05)