Table 3 Brain pharmacokinetics study of Cur-ME and Cur-Sol in adult zebrafish (n = 8)
Parameter | Unit | Value | |
|---|---|---|---|
Cur-Sol | Cur-ME | ||
t1/2 | Min | 21.088 ± 3.276 | 35.627 ± 6.519 |
Tmax | Min | 5.000 | 5.000 |
Cmax | μg/brain | 0.104 ± 0.013 | 0.203 ± 0.061 |
AUC 0-t | μg/brain*min | 2.409 ± 0.218 | 4.622 ± 0.443 |
AUC 0-inf_obs | μg/brain*min | 2.455 ± 0.224 | 5.045 ± 0.459 |
AUMC 0-inf_obs | μg/brain*min^2 | 65.325 ± 13.160 | 219.294 ± 45.875 |
MRT 0-inf_obs | Min | 26.441 ± 3.720 | 43.513 ± 8.302 |