Spectrophotometric studies of low-cost method for determination of ceftriaxone using a novel charge transfer acceptor, N-(2,4-dinitro-1-naphthyl)-p-toluenesulphonamide

Future Journal of Pharmaceutical Sciences

Table 6 Assay results of different commercial brands of CFR dosage forms

Brands coded	Proposed method^a (%) ± SD	95% CI (of 6.832 μg/ml)	Official method^a (%) ± SD	P-value^b F test T test
Du®	103.32 ± 0.39	7.059 ± 0.029	104.39 ± 1.00	0.192 0.106
Dfx®	102.14 ± 0.29	6.978 ± 0.022	101.90 ± 0.59	0.318 0.390
Sy®	103.16 ± 0.32	7.000 ± 0.050	103.17 ± 0.56	0.365 0.953
Ebt®	102.46 ± 0.71	7.022 ± 0.022	102.69 ± 2.54	0.074 0.872

^aMean values, n = 6. Content of ceftriaxone stated by USP, 2007 = 90–115%
^bStatistical analyses done between the results obtained from the proposed method and the BP official HPLC method