Table 3 Effect of hesperetin on the absorption of metoprolol
From: Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats
Time (Min) | MTL (50 µg/mL) | MTL + QDN (50 µg/mL) | MTL + HSP (25 µg/mL) | MTL + HSP (50 µg/mL) | MTL + HSP (100 µg/mL) |
|---|---|---|---|---|---|
10 | 4.525 ± 1.084 | 6.524 ± 1.423* | 5.688 ± 1.353NS | 7.466 ± 1.220* | 8.584 ± 1.235** |
20 | 6.858 ± 1.240 | 8.878 ± 1.685** | 6.256 ± 1.402NS | 9.658 ± 1.062** | 10.685 ± 1.508** |
30 | 7.128 ± 1.536 | 11.581 ± 2.458** | 8.633 ± 1.355NS | 10.763 ± 2.284** | 12.362 ± 1.685** |
40 | 8.365 ± 2.121 | 14.251 ± 2.120*** | 9.745 ± 1.834NS | 12.654 ± 1.665** | 15.236 ± 2.263*** |
50 | 10.968 ± 1.489 | 17.260 ± 2.285*** | 12.636 ± 2.108* | 14.759 ± 2.352** | 18.896 ± 2.585*** |
60 | 12.562 ± 1.725 | 19.514 ± 3.561*** | 14.684 ± 1.853* | 18.362 ± 2.515** | 20.655 ± 3.687*** |