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Table 6 Organ distribution at different time points of radiolabelled nanoparticles after oral administration (calculated as percentage of initial radioactivity)

From: Targeting efficacy and anticancer activity of polymeric nanoparticles of SN-38 on colon cancer cell lines

Formulation

Time

Heart

Liver

Spleen

Kidney

Lung

Stomach

Small intestine

Colon and rectum

CsENP

After 2 h

0

0

0

0

0

0.03 ± 0.003

36.1 ± 1.4

1.3 ± 0.1

After 4 h

0

0

0

0

0

0.01 ± 0.001

13.5 ± 2.4

87.8 ± 0.02

After 6 h

0

1.4 ± 0.05

0

1.03 ± 0.002

0

0

0

18.2 ± 0.005

After 20 h

0

1.6 ± 0.09

0.05 ± 0.01

2.3 ± 0.03

0

0

0

0

  1. Data are expressed as percentage released of total radioactivity in nanoparticles administered
  2. The values represent mean ± S.D (n = 3)