Table 2 Phytomedicinal compounds in pre-clinical and clinical trials
Phytomedicinal compounds | Source | Animal model | Pre-Clinical evidences | References |
|---|---|---|---|---|
Quercetin, coumarin | Melilotus indicus | Mice | Significant anticancerous effect were seen in quercetin-coumarin combination treated animals against skin cancer | [203] |
Hexadecanoic, Octadecanoic acid | Raphanus sativus | Chicken-chorioallantoic membrane | Down-regulates the expression of iNOS, TNF-α, ROS, and NF-kβ with significant anti-angiogenic effects | [204] |
Carvocrol, trans-caryophyllene | Wedelia chinensis | C57BL/6 mice | Target lung cancer by scavenging free radicals | [205] |
Polyphenols (plant methanol extract) | Sphagneticola calendulacea | Swiss albino mice | Strong antineoplastic activity against Ehrlich ascites carcinoma by inhibiting the proliferation, decreasing tumor weight and by increasing the apoptosis | [206] |
Triptolide | Tripterygium wilfordii | Balb/c-nu mice | Shows Antitumor activity by inducing apoptosis and regulating MMP-2, Sorcin and vascular endothelial growth factor expression | [207] |
Deoxyelephantopin | Elephantopus scaber | Male swiss albino mice | Reduced tumor volume in Murine ehrlich ascites carcinoma | [208] |
B-sitosterol, palmitic acid | Nitraria retusa | Balb/c mice | Antitumor activity by inhibiting the tumor growth | [209] |
Isoegomaketone | Perilla frutescens | Tumor-xenograft nude mice | Suppressed Hepatocellular carcinoma tumor growth via blocking PI3K/Akt signaling pathway | [210] |
Oridonin | Rabdosia rubescens | Athymic nude mice | Inhibited growth of xenograft in athymic nude mice | [211] |
Phytomedicinal compounds | Structure | Nature of compound | Clinical evidences | Clinical Trials. Govt. No |
|---|---|---|---|---|
Genistein |
| Flavonoid | The last update of this study was posted September 10, 2019. Study results are still awaited | NCT01126879 |
Polyphenols (green tea) | Compounds Mixture | Phenolic | No study results posted for clinical evidence and still work is going on in prostate cancer treatment | NCT01912820 |
Lycopene |
| Terpene | Study results still awaited for clinical evidence against prostate cancer | NCT00006078 |
Mistletoe | Compounds Mixture | Alkaloid | Study is not completed, and last update posted June 6, 2018 and no result posted | NCT02948309 |
Gemcitabine |
| Flavonoid | Total participants were 548 and after treatment of NSCLC patients with gemcitabine + cisplatin, the overall survival time were 9.9 months and P value of overall survival time were 0.0120 | NCT00981058 |
Curcumin |
| Polyphenol | No result posted yet against prostate cancer | NCT01917890 |
Panax ginseng | Water extract | Saponin | Study is in progress for breast cancer treatment | NCT00631852 |
Camptothecin |
| Alkaloid | Study results awaited for clinical evidence against unspecified adult solid tumor | NCT00059917 |
Berberine |
| Alkaloid | Overall status is still not known against Colorectal adenomas | NCT03281096 |
Resveratrol |
| Stilbenoid | This study was carried out against against Notch-1 signaling of Gastrointestinal tumors, results still awaited | NCT01476592 |
Epigallocatechin Gallate (EGCG) |
| Flavonoid | This study was carried out against the colorectal cancer patients, but the results is still not posted | NCT02891538 |
Namitecan |
| Alkaloid | Study have been completed against solid tumors but result not posted | NCT01748019 |
Lycopene |
| Carotenoid | Study being carried out against Colorectal cancer | NCT03167268 |
