Table 5 Microspheres formulation containing natural bioenhancer
Microspheres formulation | Bioenhancer | Application | Preparation method | % of entrapment efficiency | Biological activity | Mode of administration | Ref. |
|---|---|---|---|---|---|---|---|
Isoniazid-piperine microspheres | Piperine | Sustained Release formulation | Double emulsification method & complex coacervation method | 263Â nm | Tuberculosis | In vitro | [44] |
Acyclovir- piperine microspheres | Piperine | To boost oral bioavailability, place the medicine in the upper gastrointestinal area | Emulsification solvent evaporation method | 400–525 | Active against HSV-1 and HSV-2 herpes simplex viruses | Oral | [45] |
Famotidine-quercetin microspheres | Quercetin | Alternative for treating peptic ulcer | Ionotropic gelation method | 906 µm | Peptic ulcer | Oral | [46] |