Antidiabetic activity of mango peel extract and mangiferin in alloxan-induced diabetic rats

Future Journal of Pharmaceutical Sciences

Table 4 Effect of mango peel extract and mangiferin on serum lipid profile in the alloxan-induced type I diabetic rat

Group	Total Cholesterol (TC) (mg/dl)	Triglyceride (TGA) (mg/dl)	HDL (mg/dl)	LDL (mg/dl)	VLDL (mg/dl)
Control (Tc)	74.85 ± 0.95	123.49 ± 1.31	26.07 ± 0.89	24.08 ± 1.35	24.69 ± 0.26
Alloxan (Ta)	88.64 ± 1.28**	135.16 ± 1.28**	22.46 ± 0.53**	38.18 ± 1.34**	27.03 ± 0.25**
Alloxan + Extract (Tae)	72.24 ± 1.08^#	126.04 ± 1.40^#	28.79 ± .1.10^#	18.24 ± 1.94*	25.20 ± 0.28^#
Alloxan + Mangiferin (Tam)	77.5 ± 1.05^#	127.38 ± 1.15*	28.16 ± 1.16^#	23.85 ± 1.48^#	25.47 ± 0.23*

Values are mean ± SEM (n = 6); *Significant at 5% level, **Significant at 1% level and ^#Not significant
The fluctuations of serum total cholesterol, triglyceride, HDL, LDL, and VLDL levels in different groups are stated in Table 4. Ta group has higher serum cholesterol, triglyceride, HDL, LDL, and VLDL levels, and they are significantly different (p < 0.01) than the Tc group. Tae group had a significant difference (p < 0.05) in LDL levels compared with the control group. Tam group had a significant difference (p < 0.05) in triglyceride and VLDL levels when compared with the control group