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Table 3 Verapamil's impact on the movement of ranolazine from the rat everted ileum's mucosal to serosal side (n = 6)

From: Naringenin alters the pharmacokinetics of ranolazine in part through the inhibition of cytochrome P450 (3A4) and P-glycoprotein

Time (min)

Ranolazine (50 μM)

Ranolazine (50 μM) + verapamil (10 μM)

Ranolazine (50 μM) + verapamil (50 μM)

Ranolazine (50 μM) + verapamil (100 μM)

Ranolazine (50 μM) + verapamil (200 μM)

10

9.35 ± 0.94

10.72 ± 0.83*

13.54 ± 1.36*

16.69 ± 1.54*

16.01 ± 0.97

20

14.02 ± 0.83

18.08 ± 0.79*

21.24 ± 1.71*

24.73 ± 1.24*

25.82 ± 1.88

30

21.12 ± 1.45

23.26 ± 1.22*

25.66 ± 1.20*

25.77 ± 3.31*

28.35 ± 1.96

40

20.83 ± 1.24

24.58 ± 0.95*

28.17 ± 1.14*

30.98 ± 1.87*

32.11 ± 1.7

50

20.58 ± 1.35

27.00 ± 0.88*

29.9 ± 1.81*

32.51 ± 1.19*

33.11 ± 1.36

60

20.31 ± 1.56

27.98 ± 1.03*

31.04 ± 1.87*

36.47 ± 1.38*

37.21 ± 1.15

  1. *p < 0.05, when compared to ranolazine treatment alone