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Future Journal of Pharmaceutical Sciences
Fig. 3 | Future Journal of Pharmaceutical Sciences

Fig. 3

From: Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Fig. 3

Time profiles of Mean plasma concentration–time of Paracetamol; following an oral administration of Paracetamol to rats with or without diosmin (n = 6). (Circles) Control (paracetamol); (squares) with 100 mg/kg Silymarin and paracetamol (300 mg/kg); (traingles) with 50 mg/kg chlorzoxazone and paracetamol (300 mg/kg); (inverted traingles) paracetamol with chlorzoxazone (100 mg/kg). All values are mean ± SD. Bars represent the standard deviation. *P < 0.01, compared to the paracetamol control group (Two-way ANOVA followed by Bonferroni post-tests to compare each column to column). PCM, Paracetamol

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