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Future Journal of Pharmaceutical Sciences
Fig. 4 | Future Journal of Pharmaceutical Sciences

Fig. 4

From: Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Fig. 4

Time profiles of Mean plasma concentration–time of NAPQI following an oral administration of paracetamol to rats with or without Silymarin and Chlorzoxazone (n = 6). (Circles) Control (paracetamol); (squares) paracetamol with silymarin (100 mg/kg); (traingles) paracetamol with chlorzoxazone (50 mg/kg); (inverted traingles) paracetamol with chlorzoxazone (100 mg/kg). All values are Mean ± SD. Bars represent the standard deviation. *p < 0.01 compared to the paracetamol control group (Two-way ANOVA followed by Bonferroni post-tests to compare each column to column). PCM, Paracetamol; NAPQI, N-acetyl-p-benzoquinoneimine

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