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Future Journal of Pharmaceutical Sciences
Fig. 5 | Future Journal of Pharmaceutical Sciences

Fig. 5

From: Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Fig. 5

Histopathological examination of hepatoprotective activity of Chlorzoxazone and Silymarin when administered along with Paracetamol (300 mg/kg). A (Control). B Represents the Liver Histology section of rats treated with Paracetamol; ballooning degeneration, vascular congestion, sinusoidal dilatation, Central vein (CV), and steatosis;(clear vacuoles contained lipid in life) were seen in Paracetamol treated group C, D Represents the Liver Histology section of rats treated with paracetamol and Chlorzoxazone 50 mg/kg & 100 mg/kg; E Represents the Liver Histology section of rats treated with paracetamol and silymarin 100 mg/kg. The images from C–E show a significant improvement in the hepatic markers with scattered cytoplasmic vacuolization indicating the hepatic protective property of Chlorzoxazone and Silymarin

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