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Future Journal of Pharmaceutical Sciences
Fig. 6 | Future Journal of Pharmaceutical Sciences

Fig. 6

From: Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Fig. 6

Histopathologically examined the nephroprotective activity of Silymarin and Chlorzoxazone when administered along with Paracetamol (300 mg/kg). A (Control). B Represents the Kidney Histology section of rats treated with Paracetamol; pathological changes, including glomerular atrophy, degenerated tubular structure, leukocyte infiltration, and numerous tubular casts, can be seen. C, D Represents the Kidney Histology section of rats treated with paracetamol and chlorzoxazone 50 and 100 mg/kg; E Represents the Liver Histology section of rats treated with paracetamol and silymarin 100 mg/kg. The images from C–E show a significant improvement in the kidney functioning markers (C–E) with renal lesions, which were remarkably ameliorated by treatment with Chlorzoxazone and Silymarin

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