Table 1 Pharmacokinetic parameters of Paracetamol (300Â mg/kg) following an oral administration of Paracetamol to rats with or without silymarin (100Â mg/kg) and chlorzoxazone (50 and 100Â mg/kg)
Time (h) | Paracetamol (300 mg/kg) | Paracetamol + silymarin (100 mg/kg) | Paracetamol + chlorzoxazone (50 mg/kg) | Paracetamol + chlorzoxazone (100 mg/kg) |
|---|---|---|---|---|
Cmax (μg/mL) | 8.078 ± 1.344 | 10.749 ± 1.779 | 13.590 ± 1.345*** | 15.823 ± 1.827*** |
AUC0–12 (μg/mL × h) | 44.419 ± 8.798 | 61.816 ± 12.896** | 68.361 ± 8.609*** | 71.936 ± 5.500*** |
AUC0–∞ (μg/mL × h) | 62.058 ± 16.801 | 94.118 ± 29.068*** | 89.145 ± 19.831*** | 89.287 ± 13.219*** |
tmax (h) | 1.125 ± 0.586 | 1 ± 0.000 | 1.167 ± 0.517 | 1.333 ± 0.408 |
t1/2 (h) | 5.469 ± 2.128 | 6.916 ± 2.708 | 5.707 ± 3.820 | 5.619 ± 1.575 |
MRT (h) | 9.166 ± 3.059 | 10.765 ± 3.841 | 10.316 ± 4.329 | 11.008 ± 1.656 |
CL/F (mL/h) | 0.281 ± 0.109 | 0.182 ± 0.046 | 0.187 ± 0.042 | 0.183 ± 0.030 |
Vz/F (mL/kg) | 1.987 ± 0.563 | 1.694 ± 0.403 | 1.398 ± 0.599 | 1.176 ± 0.248 |
Vss/F (mL/kg) | 2.336 ± 0.528 | 1.850 ± 0.474 | 1.440 ± 0.424 | 1.245 ± 0.129 |