Table 2 NAPQI pharmacokinetic parameters following an oral after the oral administration of paracetamol (300 mg/kg) with or without silymarin (100 mg/kg) and chlorzoxazone (50 and 100 mg/kg) to rats

0.579 ± 0.134

0.514 ± 0.056

0.434 ± 0.071^*

0.300 ± 0.122^*

4.089 ± 0.521

4.133 ± 0.455

6.451 ± 8.058

2.949 ± 0.386^*

7.892 ± 4.262

5.770 ± 0.886^*

5.123 ± 1.305^*

5.730 ± 4.549^*

2.166 ± 0.983

2.833 ± 1.834

2.667 ± 1.033

1.750 ± 0.612

9.927 ± 8.190

5.351 ± 1.957

8.287 ± 4.190

5.656 ± 11.250^*