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Table 3 Effect of silymarin 100 mg/kg and chlorzoxazone (50 and 100 mg/kg) on the serum biochemical parameters in Paracetamol (300 mg/kg) induced hepatotoxicity and in wistar rats

From: Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Treatment

SGOT (U/L)

SGPT/(U/L)

ALP (U/L)

TP (g/L)

TB (mg/dL)

Control

122.661 ± 22.073

62.754 ± 16.371

151.683 ± 19.147

8.942 ± 1.796

0.539 ± 0.173

PCM (300 mg/kg)

345.236 ± 37.674

154.365 ± 25.140

407.847 ± 76.111

19.333 ± 4.065

2.674 ± 0.242

PCM + silymarin (100 mg/kg)

135.497 ± 22.430*

72.314 ± 10.951*

176.595 ± 22.706*

12.299 ± 3.540*

0.762 ± 0.211*

PCM + chlorzoxazone (50 mg/kg)

258.356 ± 49.151*

106.157 ± 21.251

219.229 ± 39.558*

13.960 ± 2.587*

1.129 ± 0.433*

PCM + chlorzoxazone (100 mg/kg)

142.434 ± 27.761*

80.774 ± 11.735*

167.008 ± 24.070*

11.052 ± 3.495*

0.899 ± 0.289*

  1. SGPT, Serum glutamate pyruvic transaminase; SGOT, Serum glutamate oxaloacetic transaminase; ALP, Alkaline phosphatase; TB, Total bilirubin; IB, Indirect bilirubin; All values are mean ± SD. A one-way ANOVA followed by Tukey’s post hoc test to perfume multiple comparisons
  2. *Significantly different at p < 0.05, from paracetamol group