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Table 4 Effect of silymarin 100 mg/kg and chlorzoxazone (50 and 100 mg/kg) on the serum biochemical parameters in Paracetamol (300 mg/kg) induced nephrotoxicity and in wistar rats

From: Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Treatment

Urea (mg/dL)

BUN (mg/dL)

Uric acid (mg/dL)

Creatinine (mg/dL)

Control

40.016 ± 12.796

17.457 ± 3.004

7.782 ± 3.282

0.651 ± 0.248

PCM (300 mg/kg)

93.683 ± 14.862

50.404 ± 11.091

12.670 ± 3.435

7.154 ± 1.672

PCM + silymarin (100 mg/kg)

43.303 ± 11.921*

23.736 ± 7.572*

8.319 ± 3.106*

1.259 ± 0.410*

PCM + chlorzoxazone (50 mg/kg)

46.552 ± 11.111*

35.066 ± 12.998

8.919 ± 3.617

1.381 ± 0.254*

PCM + chlorzoxazone (100 mg/kg)

42.838 ± 13.209*

25.815 ± 8.785*

8.479 ± 2.226*

1.299 ± 0.524*

  1. Urea, BUN, uric acid, and creatinine; All values are Mean ± SD. A one-way ANOVA followed by Tukey’s post hoc test to perfume multiple comparisons. *Significantly different at p < 0.05, from paracetamol group