In vitro characterization of self-emulsifying drug delivery system-based lipsticks loaded with ketoconazole

Future Journal of Pharmaceutical Sciences

Table 2 Composition of formulations as per randomized runs in Box–Behnken design

Formulation code	Castor oil (ml)	SEDDS (ml)	Beeswax (gm)	Carnauba Wax (gm)	Lanolin (gm)	Ghee (ml)	BHA (gm)	TiO₂ (gm)
F1	2.3	1	*1.1*	*0.35*	0.3	1	0.002	0.02
F2	2.3	1	*1.1*	*0.15*	0.3	*0.5*	0.002	0.02
F3	2.3	1	*1.4*	*0.15*	0.3	*0.75*	0.002	0.02
F4	2.3	1	*0.8*	*0.25*	0.3	1	0.002	0.02
F5	2.3	1	*1.4*	*0.35*	0.3	*0.75*	0.002	0.02
F6	2.3	1	*0.8*	*0.35*	0.3	*0.75*	0.002	0.02
F7	2.3	1	*0.8*	*0.25*	0.3	*0.5*	0.002	0.02
F8	2.3	1	*1.4*	*0.25*	0.3	1	0.002	0.02
F9	2.3	1	*1.4*	*0.25*	0.3	*0.5*	0.002	0.02
F10	2.3	1	*1.1*	*0.25*	0.3	*0.75*	0.002	0.02
F11	2.3	1	*1.1*	*0.35*	0.3	*0.5*	0.002	0.02
F12	2.3	1	*0.8*	*0.15*	0.3	*0.75*	0.002	0.02
F13	2.3	1	*1.1*	*0.25*	0.3	*0.75*	0.002	0.02
F14	2.3	1	*1.1*	*0.25*	0.3	*0.75*	0.002	0.02
F15	2.3	1	*1.1*	*0.15*	0.3	1	0.002	0.02

*Rows highlighted in italic represent the central values of experimental design, while columns indicated by bolditalic background are independent factors