Development and validation of ICPMS methods for simultaneous determination of elemental impurities in topical cream containing ximenynic acid

Future Journal of Pharmaceutical Sciences

Table 11 Table for cumulative RSD for method precision and intermediate precision

Element	Analyst	1	2	3	4	5	6	Mean	SD	%RSD
Vanadium	1	9.4547	10.5279	9.6006	9.5205	9.5716	9.7889	9.8782	0.3130	3.17
Vanadium	2	10.1117	10.0616	10.1082	10.0434	9.8920	9.8567	9.8782	0.3130	3.17
Cobalt	1	9.3576	10.3086	9.3929	9.3604	9.3646	9.4586	9.6747	0.3047	3.15
Cobalt	2	10.0188	9.8334	9.8308	9.8461	9.6734	9.6516	9.6747	0.3047	3.15
Nickel	1	22.0298	23.6646	21.7001	21.7120	21.4316	21.6740	22.3205	0.7052	3.16
Nickel	2	23.2205	22.9326	22.8481	22.4799	22.1422	22.0103	22.3205	0.7052	3.16
Arsenic	1	0.5218	0.5681	0.5205	0.5287	0.5273	0.5227	0.5360	0.0139	2.59
Arsenic	2	0.5474	0.5443	0.5426	0.5415	0.5390	0.5279	0.5360	0.0139	2.59
Cadmium	1	0.8007	0.8581	0.7853	0.7915	0.8017	0.8178	0.8090	0.0194	2.40
Cadmium	2	0.8200	0.8074	0.8045	0.8168	0.8151	0.7890	0.8090	0.0194	2.40
Mercury	1	0.0926	0.1029	0.0938	0.0931	0.0928	0.0941	0.0947	0.0028	2.96
Mercury	2	0.0949	0.0949	0.0957	0.0943	0.0932	0.0937	0.0947	0.0028	2.96
Lead	1	0.1835	0.2018	0.1852	0.1845	0.1846	0.1858	0.1876	0.0490	2.61
Lead	2	0.1887	0.1883	0.1894	0.1886	0.1850	0.1862	0.1876	0.0490	2.61