Table 1 Effects of sub-chronic oral administration of P. thyrsiflorus leaf extract (PLE) and acetaminophen (ACP) on relative organ weights (ROW) of female and male Wistar rats (n = 5/sex)
From: Toxicity assessment of Phlogacanthus thyrsiflorus, a traditionally used anthelmintic plant of India
G-I Control | G-II PLE 200 mg/kg | G-III PLE 400 mg/kg | G-IV PLE 800 mg/kg | G-V ACP 50 mg/kg | Satellite groups | |||
|---|---|---|---|---|---|---|---|---|
G-VI | G-VII | G-VIII | ||||||
Control | PLE 800 mg/kg | ACP 50 mg/kg | ||||||
Female | ||||||||
Heart | 0.63 ± 0.04 | 0.58 ± 0.01 | 0.60 ± 0.01 | 0.67 ± 0.01 | 0.60 ± 0.02 | 0.60 ± 0.02 | 0.67 ± 0.02 | 0.61 ± 0.02 |
Liver | 5.13 ± 0.18 | 4.90 ± 0.16d | 3.86 ± 0.07d | 5.12 ± 0.17d | 7.12 ± 0.11a | 4.80 ± 0.15 | 4.41 ± 0.15 g | 5.92 ± 0.11f |
Brain | 0.84 ± 0.02 | 0.86 ± 0.02 | 0.81 ± 0.03 | 0.82 ± 0.02 | 0.81 ± 0.02 | 0.83 ± 0.02 | 0.83 ± 0.06 | 0.86 ± 0.02 |
Spleen | 0.41 ± 0.05 | 0.39 ± 0.01d | 0.38 ± 0.01d | 0.39 ± 0.03d | 0.45 ± 0.02b | 0.40 ± 0.02 | 0.38 ± 0.01 | 0.41 ± 0.01 |
Adrenal | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.02 ± 0.00 |
Kidney (left) | 0.81 ± 0.01 | 0.82 ± 0.02e | 0.81 ± 0.02d | 0.82 ± 0.01e | 0.84 ± 0.01a | 0.82 ± 0.01 | 0.81 ± 0.01 | 0.81 ± 0.02 |
Kidney (right) | 0.84 ± 0.02 | 0.83 ± 0.01d | 0.83 ± 0.02d | 0.84 ± 0.01e | 0.86 ± 0.01c | 0.83 ± 0.01 | 0.82 ± 0.01 | 0.83 ± 0.01 |
Ovary | 0.05 ± 0.00 | 0.05 ± 0.00 | 0.06 ± 0.00 | 0.05 ± 0.00 | 0.05 ± 0.00 | 0.05 ± 0.00 | 0.05 ± 0.00 | 0.05 ± 0.00 |
Male | ||||||||
Heart | 0.63 ± 0.01 | 0.58 ± 0.01 | 0.63 ± 0.00 | 0.59 ± 0.01 | 0.61 ± 0.03 | 0.61 ± 0.02 | 0.61 ± 0.01 | 0.60 ± 0.03 |
Liver | 7.00 ± 0.12 | 7.10 ± 0.29d | 7.12 ± 0.13d | 6.99 ± 0.14d | 8.01 ± 0.11a | 6.16 ± 0.19 | 6.22 ± 0.13 g | 6.58 ± 0.11f |
Brain | 1.01 ± 0.06 | 1.00 ± 0.01 | 0.99 ± 0.02 | 0.99 ± 0.01 | 1.00 ± 0.03 | 0.97 ± 0.02 | 0.98 ± 0.03 | 0.97 ± 0.02 |
Spleen | 0.40 ± 0.03 | 0.39 ± 0.02 | 0.37 ± 0.01 | 0.38 ± 0.02 | 0.39 ± 0.01 | 0.41 ± 0.01 | 0.39 ± 0.01 | 0.40 ± 0.02 |
Adrenal | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.03 ± 0.00 |
Kidney (left) | 0.83 ± 0.01 | 0.82 ± 0.00 | 0.82 ± 0.03 | 0.83 ± 0.01 | 0.83 ± 0.01 | 0.82 ± 0.02 | 0.83 ± 0.02 | 0.83 ± 0.02 |
Kidney (right) | 0.85 ± 0.02 | 0.84 ± 0.00 | 0.84 ± 0.02 | 0.85 ± 0.03 | 0.83 ± 0.03 | 0.84 ± 0.02 | 0.85 ± 0.02 | 0.85 ± 0.01 |
Testis (left) | 0.72 ± 0.02 | 0.73 ± 0.02 | 0.72 ± 0.02 | 0.72 ± 0.02 | 0.73 ± 0.02 | 0.73 ± 0.03 | 0.72 ± 0.02 | 0.72 ± 0.02 |
Testis (right) | 0.76 ± 0.03 | 0.76 ± 0.02 | 0.77 ± 0.03 | 0.76 ± 0.03 | 0.77 ± 0.03 | 0.77 ± 0.03 | 0.76 ± 0.02 | 0.76 ± 0.03 |