Toxicity assessment of Phlogacanthus thyrsiflorus, a traditionally used anthelmintic plant of India

Deori, Khirod; Soren, Amar Deep; Yadav, Arun K.

doi:10.1186/s43094-023-00502-3

Future Journal of Pharmaceutical Sciences

Table 3 Effects of sub-chronic oral administration of P. thyrsiflorus leaf extract (PLE) and acetaminophen (ACP) on some biochemical parameters of female Wistar rats (n = 5)

From: Toxicity assessment of Phlogacanthus thyrsiflorus, a traditionally used anthelmintic plant of India

	G-I Control	G-II PLE 200 mg/kg	G-III PLE 400 mg/kg	G-IV PLE 800 mg/kg	G-V ACP 50 mg/kg	Satellite groups
						G-VI	G-VII	G-VIII
						Control	PLE 800 mg/kg	ACP 50 mg/kg
Female
SGOT (U/L)	135.82 ± 0.66	136.80 ± 0.41^c	136.84 ± 0.95^c	137.48 ± 0.30^c	260.44 ± 0.11^a	136.61 ± 0.83	136.75 ± 0.88^e	156.61 ± 0.71^d
SGPT (U/L)	70.59 ± 0.81	70.16 ± 0.43^c	70.80 ± 0.83^c	71.43 ± 0.53^c	120.72 ± 0.08^a	67.93 ± 0.00	71.19 ± 0.73^e	90.94 ± 0.94^d
ALP (U/L)	74.43 ± 2.30	76.72 ± 1.80^dc	71.33 ± 3.19^c	76.28 ± 2.70^c	247.53 ± 1.34^a	87.13 ± 2.76	81.04 ± 3.73^de	179.94 ± 3.02^d
TBI (mg/dl)	0.62 ± 0.02	0.53 ± 0.04^ac	0.63 ± 0.01^c	0.61 ± 0.00^c	0.81 ± 0.00^a	0.59 ± 0.00	0.62 ± 0.00^e	0.69 ± 0.11^d
ALB (gm/dl)	3.16 ± 0.08	3.48 ± 0.27^c	3.85 ± 0.24^c	3.98 ± 0.06	5.50 ± 0.16^b	3.93 ± 0.16	3.77 ± 0.18	3.60 ± 0.10
Crt (mg/dl)	0.67 ± 0.00	0.66 ± 0.00^c	0.63 ± 0.01^c	0.64 ± 0.01^c	0.87 ± 0.00^a	0.63 ± 0.00	0.65 ± 0.01	0.68 ± 0.01
Urea (mg/dl)	19.26 ± 0.37	19.26 ± 0.37^c	19.22 ± 0.39^c	19.31 ± 0.43^c	26.78 ± 0.53^a	19.35 ± 0.97	18.98 ± 0.15	19.70 ± 0.33
U/A (mg/dl)	2.5 ± 0.11	2.5 ± 0.05	2.66 ± 0.05	2.71 ± 0.02	3.40 ± 0.00	2.79 ± 0.03	2.76 ± 0.02	2.40 ± 0.10
Na⁺ (mEq/L)	139.20 ± 0.58	138.12 ± 1.03	138.00 ± 0.83	139.73 ± 0.34	140.88 ± 0.01	141.35 ± 1.80	142.25 ± 0.24	138.97 ± 1.18
K⁺ (mEq/L)	3.59 ± 0.05	3.63 ± 0.05	3.64 ± 0.05	3.70 ± 0.05	3.65 ± 0.05	3.64 ± 0.06	7.63 ± 0.11	3.77 ± 0.06
Male
SGOT (U/L)	151.60 ± 0.52	152.53 ± 0.98^b	153.28 ± 1.4^b	150.67 ± 0.10^b	372.68 ± 0.03^a	152.89 ± 0.04	152.00 ± 0.00^f	202.08 ± 0.07^d
SGPT (U/L)	76.58 ± 0.99	77.91 ± 1.03^b	77.21 ± 1.13^b	78.52 ± 0.01^b	121.60 ± 0.07^a	77.31 ± 0.95	79.52 ± 0.01	77.19 ± 0.74
ALP (U/L)	94.04 ± 3.3	95.43 ± 3.9^b	91.97 ± 5.58^b	89.14 ± 4.13^b	290.71 ± 4.40^a	95.45 ± 3.5	97.90 ± 2.7^f	171.25 ± 1.11^d
TBI (mg/dl)	0.67 ± 0.01	0.68 ± 0.00^b	0.67 ± 0.00^b	0.66 ± 0.00^b	0.93 ± 0.01^a	0.61 ± 0.00	0.63 ± 0.01^f	0.74 ± 0.01^d
ALB (gm/dl)	4.28 ± 0.01	4.27 ± 0.03	4.24 ± 0.01	4.32 ± 0.02	4.06 ± 0.07	4.40 ± 0.1	4.41 ± 0.02	4.40 ± 0.01
Crt (mg/dl)	0.65 ± 0.00	0.60 ± 0.01^c	0.66 ± 0.00	0.62 ± 0.00	0.69 ± 0.000	0.60 ± 0.00	0.62 ± 0.00	0.68 ± 0.02^e
Urea (mg/dl)	25.67 ± 0.66	26.14 ± 0.93^b	27.15 ± 0.25^b	27.58 ± 0.27^b	38.40 ± 0.91^a	26.87 ± 0.41	26.87 ± 0.41	26.73 ± 0.42
U/A (mg/dl)	2.60 ± 0.12	2.60 ± 0.12^b	2.65 ± 0.11^b	2.70 ± 0.06^b	4.22 ± 0.00^a	2.83 ± 0.04	2.79 ± 0.50	2.80 ± 0.03
Na⁺ (mEq/L)	140.30 ± 0.67	139.78 ± 0.69	140.46 ± 0.71	140.39 ± 1.09	141. ± 0.83	140.81 ± 1.13	139.98 ± 0.41	141.37 ± 0.81
K⁺ (mEq/L)	3.69 ± 0.03	3.73 ± 0.05	3.76 ± 0.03	3.76 ± 0.03	3.78 ± 0.04	3.72 ± 0.05	3.77 ± 0.03	3.84 ± 0.00

Data are expressed as mean ± S.E.M.; Treatment: G-II to G-V = 4 weeks and G-VII to G-VIII = 6 weeks
Female: ^ap < 0.001, ^bp < 0.01 as compared to control values; ^cp < 0.001 as compared to ACP values; ^dp < 0.001 as compared to satellite control values; ^ep < 0.001 as compared to satellite ACP values, one way ANOVA
Male: ^ap < 0.001 as compared to control value; ^bp < 0.001, ^cp < 0.01 as compared to ACP values; ^dp < 0.001, ^ep < 0.01 as compared to satellite control values; ^fp < 0.001 as compared to satellite ACP values, one way ANOVA

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