A stability indicating UPLC method development and validation for the simultaneous estimation of nateglinide and metformin hydrochloride in bulk and tablet dosage form

Future Journal of Pharmaceutical Sciences

Table 10 Degradation data for metformin HCl

S.NO	Degradation condition	Peak area	% Recovery	% Drug degradation	Peak purity
S.NO	Degradation condition	Peak area	% Recovery	% Drug degradation	Purity angle	Purity threshold	Pass/Fail
1	Acid	2,443,017	85.7	14.2	0.124	1.254	Pass
2	Alkali	2,465,075	86.5	13.4	0.131	1.231	Pass
3	Peroxide	2,401,507	84.2	15.7	0.108	1.227	Pass
4	Thermal	2,709,854	95.1	4.8	0.136	1.251	Pass
5	Photolysis	2,685,412	94.2	5.7	0.117	1.232	Pass
6	Hydrolysis	2,720,156	95.4	4.5	0.152	1.209	Pass