Table 9 Degradation data for nateglinide
S.NO | Degradation condition | Peak area | % Recovery | % Drug degradation | Peak purity | ||
|---|---|---|---|---|---|---|---|
Purity angle | Purity threshold | Pass /Fail | |||||
1 | Acid | 457,512 | 87.3 | 12.7 | 1.232 | 8.025 | Pass |
2 | Alkali | 455,849 | 87 | 13 | 1.217 | 8.054 | Pass |
3 | Peroxide | 450,125 | 85.9 | 14.1 | 1.249 | 8.173 | Pass |
4 | Thermal | 479,856 | 91.6 | 8.4 | 1.263 | 8.007 | Pass |
5 | Photolysis | 500,478 | 95.5 | 4.5 | 1.248 | 8.063 | Pass |
6 | Hydrolysis | 502,154 | 95.8 | 4.2 | 1.252 | 8.077 | Pass |