Combined and comparative analytical studies with stability studies and validation for estimation of prenoxdiazine HCl in pharmaceutical dosage form

Future Journal of Pharmaceutical Sciences

Table 2 Forced degradation study using liquid chromatography technique

Stress condition	Optimized time period	% Reduction in area	Peak purity angle	Peak purity threshold
Untreated	–	–	0.12	0.587
Acid	1 day	16.34	0.586	1.143
Base	4 h	6.96	0.475	0.643
H₂O₂	3 days	8.15	0.586	1.110
Thermal	1 day	4.23	0.417	0.794
Photo	4.5 day	6.77	0.090	0.575