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Table 1 Selection of level for BBD design

From: Box–Behnken design-assisted optimization of RP-HPLC method for the estimation of evogliptin tartrate by analytical quality by design

Independent variable

Level

+ 1

0

− 1

% Organic modifier (ml)

65

60

55

pH

5.0

4.5

4.0

Flow rate (ml/min)

1.2

1

0.8