Characterization, cellular uptake in Caco-2 cells and physiologically based pharmacokinetic modeling of baicalin-loaded solid lipid nanoparticles

Future Journal of Pharmaceutical Sciences

Table 1 Composition and characterization of the different BA-loaded solid lipid nanoparticles formulations

Formulation	Stearic acid	Soy lecithin	Tween 80	Volume of cold water	Speed of homogenization	Duration of homogenization	PS	PDI	ZP	EE
Formulation	(g)	(g)	(g)	(mL)	(rpm)	(min.)	(nm)	PDI	(mV)	%
F1	0.6	0.006	0.03	90	20,000	30	260.2 ± 13.5	0.22	− 21.63 ± 2.51	74.06 ± 2.32
F2	0.6	0.006	0.03	90	10,000	30	281.1 ± 9.9	0.25	− 20.85 ± 2.05	72.60 ± 0.69
F3	0.6	0.006	0.03	90	5,000	30	371.1 ± 19.73	0.44	− 23.65 ± 1.20	77.02 ± 1.67
F4	0.6	0.006	0.03	90	20,000	20	248.2 ± 1.70	0.19	− 21.00 ± 1.20	67.80 ± 2.47
F5	0.6	0.006	0.03	90	20,000	10	260.2 ± 23.76	0.22	− 21.63 ± 0.85	76.26 ± 4.24
F6	0.6	0.012	0.03	90	20,000	10	286.6 ± 12.52	0.25	− 22.10 ± 0.14	81.52 ± 0.26
F7	0.6	0.024	0.03	90	20,000	10	288.1 ± 9.05	0.24	− 20.45 ± 0.64	82.75 ± 0.92
F8	0.6	0.024	0.06	90	20,000	10	255.9 ± 20.5	0.18	− 19.20 ± 0.99	76.60 ± 1.41
F9	0.6	0.024	0.12	90	20,000	10	253.5 ± 21.85	0.24	− 18.65 ± 0.50	71.67 ± 0.69
F10	0.9	0.024	0.03	90	20,000	10	292.6 ± 21.85	0.241	− 19.45 ± 0.50	73.00 ± 0.25
F11	1.2	0.024	0.03	90	20,000	10	272.5 ± 12.4	0.22	− 22.50 ± 0.80	70.50 ± 0.50
F12	0.6	0.024	0.06	60	20,000	10	291.9 ± 30.9	0.37	− 19.45 ± 2.62	57.67 ± 5.75
F13	0.6	0.024	0.03	30	20,000	10	286.1 ± 29.96	0.23	− 18.90 ± 2.80	68.09 ± 4.31

PS Particle size, PDI Polydispersity index, ZP Zeta potential, EE Entrapment efficiency