Future Journal of Pharmaceutical Sciences

Table 2 Values of BA parameters for PBPK simulation

From: Characterization, cellular uptake in Caco-2 cells and physiologically based pharmacokinetic modeling of baicalin-loaded solid lipid nanoparticles

Parameters	Value
Molecular weight (g/mol)	446.4
pKa^a	5.0
Type	Monoprotic acid
Log P^b	1.2
Fu^c	0.11
Cl_int for CYP1A2 in HLM (µL/min/10⁶)^d	18.3
Km (µM)^e	52.3
Vmax (pmol//min/10⁶)^f	830.8

^aDissociation constants of drug
^bPartition coefficient
^cFraction of drug unbound in plasma
^dIntrinsic clearance for CYP1A2 in human liver michrosomes
^eMichaelis–Menten constant
^fMaximum metabolic rate

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