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Table 4 Analysis of pharmaceutical dosage form (Mpiviropack plus®) and application of standard addition technique by the proposed spectrophotometric methods for determination of SOF and LDV

From: Simultaneous spectrophotometric determination of recombined sofosbuvir, ledipasvir and paracetamol together as commonly repurposed drugs for COVID-19 treatment

SOF(first derivative)

LDV(zero order)

Mpiviropack plus® %recovery* ± SD

Standard addition

Mpiviropack plus® %recovery* ± SD

Standard addition

Pure taken (µg/mL)

Pure found (µg/mL)

Recovery (%)*

Pure taken (µg/mL)

Pure found (µg/mL)

Recovery (%)*

99.05 ± 0.81

1.92

1.90

98.95

101.26 ± 0.148

0.432

0.422

97.68

3.84

3.81

99.21

0.864

0.872

100.92

7.68

7.56

98.43

1.728

1.69

97.80

Mean ± SD

98.87 ± 0.397

Mean ± SD

98.80 ± 1.83

  1. *Average of three determinations