Skip to main content

Table 3 Percent yield and drug content of IB co-crystal agglomerates

From: Nicotinamide-based agglomerates of ibuprofen: formulation, solid state characterization and evaluation of tableting performance with in-silico investigation

Bach code

Yield* (%)

Drug content*

(%)

Saturation solubility* (mg/ml)

DW

PBS (pH 7.4)

IB

–

–

0.085 ± 2.32

0.435 ± 2.64

F1

85 ± 2.21

98 ± 2.25

1.1 ± 2.21

2.8 ± 2.31

F2

86 ± 2.91

96 ± 3.16

2.8 ± 3.33

4.5 ± 1.22

F3

96 ± 1.39

97 ± 3.05

3.1 ± 2.56

3.6 ± 2.36

F4

95 ± 1.91

98 ± 2.14

1.6 ± 2.47

2.7 ± 3.34

F5

96 ± 2.32

96 ± 2.16

2.9 ± 1.78

5.3 ± 2.37

F6

97 ± 1.56

99 ± 1.81

2.8 ± 2.89

4.9 ± 1.35

F7

92 ± 1.89

98 ± 2.17

2.0 ± 2.96

2.9 ± 3.37

F8

97 ± 1.78

99 ± 1.08

3.4 ± 1.36

4.8 ± 2.26

F9

98 ± 1.68

96 ± 1.45

3.8 ± 3.41

5.8 ± 1.36

  1. *Values are expressed as the mean ± SD (n = 3)