Mannose-anchored solid lipid nanoparticles loaded with atorvastatin calcium and vinpocetine as targeted therapy for breast cancer

Future Journal of Pharmaceutical Sciences

Table 5 Pharmacokinetic results of ATS and VIN subsequent single oral dose administration of SLNs, MSLNs and marketed tablet formulation {ATS (25 mg/kg), VIN (6 mg/kg)}

Pharmacokinetic parameters	SLNs		MSLNs		Marketed
Pharmacokinetic parameters	ATS	VIN	ATS	VIN	ATS	VIN
C max (µg/ml)	27.29	3.31	23.1	2.28	10.91	0.48
T max (hr)	2.07	2.05	2.21	2.15	1.93	1.87
AUC0.5–24 (mg hr/ml)	382.513	12.796	338.535	9.816	140.555	1.473
AUC0-∞ (mg hr/ml)	786.806	13.68	668.986	9.90	451.410	1.734
Relative bioavailability					1.47	5.70