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Future Journal of Pharmaceutical Sciences

Table 3 Experimental design of rotenone-induced neurotoxicity model

From: Neuroprotective action of Smilax china ethanolic bark extract in treatment of a prominent aging disorder: Parkinson’s disease induced by rotenone

Sr. no

Group

Treatment

Drug administered

Concentration

No. of animals required (n)

1

Group-1

Control

Tween 80 and 1% dimethyl sulfoxide (DMSO)

1 ml/kg; S.C

6

2

Group-2

Induction

Rotenone

1.5 mg/kg; S.C

6

3

Group-3

Standard

Levodopa + carbidopa

100 + 25 mg/kg; I.P

6

4

Group-4

Treatment-I

Rotenone + Smilax china extract

1.5 mg/kg; S.C. + 100 mg/kg; P.O

6

5

Group-5

Treatment-II

Rotenone + Smilax china extract

1.5 mg/kg; S.C. + 200 mg/kg; P.O

6

     

Total: 30

  1. The male Wistar rats utilized in this research were separated into 5 groups, each including 6 animals (Table 3)
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