Table 2 Actual and coded values of formulation parameters for 32 full factorial design
From: Optimizing pulsatile release of febuxostat for managing gout flares: a chronotherapeutic approach
Independent variables | Coded and actual values | ||
|---|---|---|---|
− 1 | 0 | + 1 | |
Concentration of HPMC K15M (mg) (X1) | 80 | 90 | 100 |
The concentration of a 1:1 mixture of aloe vera and guar gum (mg) (X2) | 80 | 90 | 100 |
Dependent variables | Constraints |
|---|---|
Y1 = Swelling index (%) | 55–75% |
Y2 = Hardness (%) | > 5 |
Y3 = Lag time (h) | 8–10 h |