Table 3 Experimental runs projected for 32 full factorial design and their observed responses
From: Optimizing pulsatile release of febuxostat for managing gout flares: a chronotherapeutic approach
Batches | Coded value | Uncoded value | Y1 % Swelling index (%) n = 3, (± S.D.) | Y2 Hardness (kg/cm2) n = 3, (± S.D.) | Y3 Lag time (h) n = 3, (± S.D.) | ||
|---|---|---|---|---|---|---|---|
X1 | X2 | X1 | X2 | ||||
B1 | − 1 | + 1 | 80 | 100 | 69.3 ± 0.14 | 3.9 ± 0.002 | 11.2 ± 0.003 |
B2 | 0 | + 1 | 90 | 100 | 62.3 ± 0.035 | 5.1 ± 0.003 | 9.9 ± 0.002 |
B3 | + 1 | + 1 | 100 | 100 | 74.81 ± 0.213 | 4.9 ± 0.004 | 10.3 ± 0.003 |
B4 | 0 | 0 | 90 | 90 | 73.2 ± 0.059 | 5.6 ± 0.001 | 9.1 ± 0.004 |
B5 | − 1 | 0 | 80 | 90 | 60.3 ± 0.0158 | 4.8 ± 0.003 | 8.8 ± 0.02 |
B6 | + 1 | 0 | 100 | 90 | 55.39 ± 0.078 | 5.8 ± 0.008 | 8.1 ± 0.004 |
B7 | + 1 | − 1 | 100 | 80 | 67.3 ± 0.054 | 6.2 ± 0.009 | 7.3 ± 0.007 |
B8 | 0 | − 1 | 90 | 80 | 68.3 ± 0.03 | 5.3 ± 0.004 | 9.3 ± 0.001 |
B9 | − 1 | − 1 | 80 | 80 | 73.65 ± 0.024 | 4.5 ± 0.009 | 10.8 ± 0.002 |
V1 | – | – | 91.71 | 101.56 | 72.53 ± 0.054 | 5.9 ± 0.001 | 8.4 ± 0.02 |
V2 | – | – | 89.34 | 94.71 | 66.42 ± 0.079 | 4.8 ± 0.003 | 9 ± 0.003 |
V3 | – | – | 95.44 | 87.44 | 62.98 ± 0.458 | 5.0 ± 0.006 | 8.9 ± 0.001 |