Fig. 4From: Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experimentsResponse surface modeling using a central composite design and Minitab 18 software A 2D contour plot showing multidimensional interactions between high-risk CPVs with response R1 B 2D contour plot showing multidimensional interactions between high-risk CPVs with response R2 C Overlaid contour plots showing analytical design space for the development of targeted RP-HPLC method as per analytical target profileBack to article page