Table 1 Analytical quality risk assessment for identification of high-risk CPVs (Critical Procedure Variables) for variation in responses (resolution and tailing factor) using RPN (Risk Priority Numbering) ranking and filtering method
Source | DF | Adjusted SS | Adjusted MS | F-Value | P-Value | Risk priority number ranking | Risk priority number filtering |
|---|---|---|---|---|---|---|---|
Risk priority ranking and filtering for Response 1 using Plackett–Burman design and Minitab software | |||||||
Model | 5 | 92.1244 | 18.4249 | 357.40 | 0.000 | – | – |
Linear | 5 | 92.1244 | 18.4249 | 357.40 | 0.000 | – | – |
CPV—A | 1 | 90.9151 | 90.9151 | 1763.53 | 0.000 | Rank 1 | High-risk |
CPV—B | 1 | 0.9804 | 0.9804 | 19.02 | 0.005 | Rank 2 | High-risk |
CPV—C | 1 | 0.0919 | 0.0919 | 1.78 | 0.230 | Rank 3 | Low-risk |
CPV—D | 1 | 0.0850 | 0.0850 | 1.65 | 0.246 | Rank 4 | Low-risk |
CPV—E | 1 | 0.0520 | 0.0520 | 1.01 | 0.354 | Rank 5 | Low-risk |
Error | 6 | 0.3093 | 0.0516 | – | – | – | – |
Total | 11 | 92.4337 | – | – | – | – | – |
Risk priority ranking and filtering for Response 2 using Plackett–Burman design and Minitab software | |||||||
CPV—A | 1 | 0.000408 | 0.000408 | 0.92 | 0.373 | Rank 4 | Low-risk |
CPV—B | 1 | 0.297675 | 0.297675 | 673.98 | 0.000 | Rank 1 | High-risk |
CPV—C | 1 | 0.000675 | 0.000675 | 1.53 | 0.263 | Rank 3 | Low-risk |
CPV—D | 1 | 0.001875 | 0.001875 | 4.25 | 0.085 | Rank 2 | Low-risk |
CPV—E | 1 | 0.000008 | 0.000008 | 0.02 | 0.895 | Rank 5 | Low-risk |
Error | 6 | 0.002650 | 0.000442 | – | – | – | – |
Total | 11 | 0.303292 | – | – | – | – | – |