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Table 2 Design metrics for DoE-based response surface methodology for high-risk CPVs (Critical Procedure Variables) and critical responses using central composite design and MINITAB 18 software

From: Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: incorporating hybrid principles of white analytical chemistry and design of experiments

Std Order

Run Order

Point Type

Blocks

CPV—A

CPV—B

Response–R1

Response–R2

7

1

− 1

1

60.0000

2.08579

5.55

1.32

11

2

0

1

60.0000

3.50000

5.56

1.11

6

3

− 1

1

74.1421

3.50000

7.85

1.11

9

4

0

1

60.0000

3.50000

5.45

1.12

13

5

0

1

60.0000

3.50000

5.62

1.13

3

6

1

1

50.0000

4.50000

1.35

2.20

5

7

− 1

1

45.8579

3.50000

1.34

1.14

4

8

1

1

70.0000

4.50000

6.54

2.22

8

9

− 1

1

60.0000

4.91421

5.45

2.55

1

10

1

1

50.0000

2.50000

1.32

1.23

2

11

1

1

70.0000

2.50000

6.85

1.25

10

12

0

1

60.0000

3.50000

5.61

1.10

12

13

0

1

60.0000

3.50000

5.50

1.12