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Table 4 Quantification of SOF, LDV and PAR in the laboratory prepared mixtures by UHPLC method

From: Rapid and validated UHPLC method for simultaneous determination of sofosbuvir, ledipasvir and paracetamol as commonly repurposed drugs for COVID-19 treatment: application in spiked human plasma

Binary mixture SOF: LDV:PAR ratios

%Recoverya

SOF

LDV

PAR

4: 0.9:5

99.61%

99.86%

100.52%

2: 1:1

98.99%

100.00%

98.68%

1: 2:1

100.31%

98.78%

99.26%

Mean ± SD

99.64 ± 0.65

99.55 ± 0.66

99.48 ± 0.93

  1. aAverage of three determinations