Table 3 Comparison of MSH3 and MSH6 genes’ fold change among the studied breast cancer patients as regards presence of toxicity
Type of toxicity | MSH3fold change Mean ± SE | MSH6fold change Mean ± SE | |
|---|---|---|---|
Presence of toxicity | Yes No | 0.086 ± 0.01 0.139 ± 0.03 | 0.179 ± 0.03 0.315 ± 0.07 |
p value | 0.133 | 0.038* | |
Peripheral neuropathy | Yes No | 0.089 ± 0.02 0.114 ± 0.02 | 0.182 ± 0.03 0.259 ± 0.05 |
p value | 0.365 | 0.145 | |
Peripheral neuropathy toxicity grade | |||
N = 68 | 0–1 | 0.127 ± 0.02 | 0.242 ± 0.03 |
N = 37 | 2–4 | 0.07 ± 0.02 | 0.136 ± 0.03 |
p value | 0.034* | 0.01* | |
Diarrhea | Yes No | 0.057 ± 0.01 0.108 ± 0.02 | 0.122 ± 0.03 0.229 ± 0.03 |
p value | 0.02* | 0.008** | |
Dyspnea | Yes No | 0.043 ± 0.01 0.102 ± 0.01 | 0.092 ± 0.04 0.218 ± 0.03 |
p value | 0.01* | 0.016* | |
Bone pain | Yes No | 0.075 ± 0.01 0.130 ± 0.03 | 0.158 ± 0.03 0.281 ± 0.05 |
p value | 0.062 | 0.024* | |
Fatigue | Yes No | 0.089 ± 0.04 0.10 ± 0.01 | 0.167 ± 0.06 0.22 ± 0.03 |
p value | 0.747 | 0.367 | |
Gastritis | Yes No | 0.096 ± 0.05 0.098 ± 0.01 | 0.178 ± 0.08 0.213 ± 0.03 |
p value | 0.956 | 0.595 | |
Nausea | Yes No | 0.091 ± 0.02 0.099 ± 0.02 | 0.211 ± 0.06 0.206 ± 0.03 |
p value | 0.819 | 0.943 | |
Vomiting | Yes No | 0.098 ± 0.02 0.097 ± 0.02 | 0.235 ± 0.06 0.202 ± 0.03 |
p value | 0.980 | 0.625 | |
Skin rash | Yes No | 0.097 ± 0.01 0.097 ± 0.07 | 0.109 ± 0.08 0.211 ± 0.03 |
p value | 0.999 | 0.448 | |
Stomatitis | Yes No | 0.013 0.095 ± 0.01 | 0.304 0.201 ± 0.02 |
p value | 0.773 | 0.649 | |